Alterations in Lipid Peroxidation and Antioxidants in Patients’ with Different Stages of Hepatitis B Virus Infection in Egypt

Persistent hepatitis B virus (HBV) infection often leads to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. The aim of this study was to estimate the oxidant/antioxidant status and liver function tests in different stages of HBV infection to investigate the role of oxidative stress in the pathogenesis of chronic liver diseases. The study was carried out on 150 control healthy persons (C) and 320 patients with HBV infection which included normal carriers (N), acute (A), chronic (CH), cirrhosis (Cl) and hepatocellular carcinoma (HCC). The study focused on the determination of malondialdehyde (MDA), non enzymatic and enzymatic antioxidant parameters and liver function profile tests. The results showed that MDA and glutathione reductase (GSR) were increased, while reduced glutathione (GSH), total glutathione s-transferase (GST), total glutathione peroxidase (GPx), superoxide dismutase (SOD) were decreased in N, A, CH, CI and HCC groups as compared to the C group. Also, the levels of total protein (TP) and albumin were decreased but alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities and total bilirubin (TB) level were increased in all studied groups as compared to the C group. This indicates that HBV induced oxidative stress, lipid peroxidation LPO, liver injury and cell death. We concluded that the determination of antioxidant system, oxidative stress and liver function tests may be considered as accurate biomarkers for determining the progression of HBV infection. Also treatment with antioxidant supplementation is very important in case of HBV infection. [Nadia Z. Shaban, Halima H. Salem, Mohamed A. Elsadany , Bahy A. Ali, Ehab M Hassona and Fayed A. K. Mogahed. Alterations in Lipid Peroxidation and antioxidants in Patients’ with different stages of Hepatitis B Virus infection in Egypt. Life Sci J 2014;11(8):960-967]. (ISSN:1097-8135). http://www.lifesciencesite.com. 141